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Last Updated: 2 years ago

Possible Interaction: Glycerol and Trehalose

supplement:

Glycerol

supplement:

Trehalose

Research Papers that Mention the Interaction

When used in combination, the glycerol and trehalose combination provides the best tissue protection.
Cryo letters  •  2019  |  View Paper
Trehalose and its combinations with biostab, sucrose or glycerol significantly increased stability of HRP2 by 57% (p < 0.001).
Malaria Journal  •  2017  |  View Paper
Glycerol anti-plasticizes the matrix with respect to the trehalose by enhancing the stability of the protein in a more rigid trehalose/water/glycerol matrix.
The analysis of the Amide I band reveals that glycerol enhances the stabilization effect of trehalose on proteins for low water content, but still liquid, systems.
The journal of physical chemistry. B  •  2014  |  View Paper
We conclude that, in our SL-based extender, a combination of 100 mM trehalose and 5% glycerol was the most adequate combination to achieving post-thawing quality in our soybean lecithin-based extender, and our results support that a synergistic effect among trehalose and glycerol exists.
Cryobiology  •  2013  |  View Paper
The synergic effect of trehalose and glycerol resulted in better cryosurvival of boar spermatozoa than that of a single cryoprotectant.
Reproduction in domestic animals = Zuchthygiene  •  2009  |  View Paper
They inhibited the response to glycerol , specifically and competitively as compared with the almost total lack of effects of the reagent on the responses to the four sugars sucrose, D-glucose, D-fructose and trehalose.
Chemical senses  •  2005  |  View Paper
These observations suggest that trehalose can be used in combination with glycerol as a cryoprotectant and that a high rate of viability can be achieved after a one-step dilution of the cryoprotectants.
Cryobiology  •  1988  |  View Paper
For both, pure and crude glycerol, the highest amount of dry biomass leveled off at about 4 g/L. While the use of crude glycerol had no effect on the final concentration of biomass, it reduced the accumulation of trehalose in the cells.
Acta biochimica Polonica  •  2017  |  View Paper
By contrast, during the secondary drying stage, glycerol significantly enhanced the stabilizing effect of trehalose in the same sample, by replacing water-trehalose H-bonds with stronger glycerol-trehalose H-bonds and stiffening the amorphous trehalose matrix.
It was found that the addition of a small amount of glycerol had a plasticizing effect on the glassy trehalose-water matrix during the primary drying stage and then reduced the bioprotective effect of trehalose.
This opportunity was used for determining how a small amount of glycerol enhances the bioprotective efficiency of trehalose during FD of lysozyme formulations.
Journal of pharmaceutical sciences  •  2017  |  View Paper
A detailed analysis of the hydrogen bonds (HBs) formed between species reveals that water and glycerol may antiplasticize the fast dynamics of lysozyme and trehalose by increasing the total number and/or the strength of the HBs they form in glassy matrices.
The journal of physical chemistry. B  •  2017  |  View Paper
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