Possible Interaction: Glycerol and Theophylline

“ Theophylline and norepinephrine alone increased glycerol outflow significantly.”

“The stimulation of lipolysis by HGH appears to be mediated by cyclic AMP since the effect of the hormone on both cyclic AMP accumulation and glycerol release are potentiated by theophylline.”

“Despite comparable basal lipolysis, the increase in glycerol output from adipocytes provoked by theophylline was higher in omega3-depleted than control rats.”

“ Theophylline enhanced the nonshivering thermogenic free fatty acid (FFA) and glycerol responses before cord occlusion, raising FFA concentrations 99% to 415 +/- 60 mueq/l (P < 0.01) and glycerol levels 87% to 526 +/- 135 mumol/l (P < 0.05).”

“Histamine and theophylline , two gastric secretagogues, significantly increased tissue glycerol content by 121 and 66%, respectively, in the isolated toad gastric mucosa.”

“In rat fat cells incubated for 15 min at 37 degrees and pH 8.5, glycerol release was highly stimulated both by norepinephrine and by theophylline.”

“ Theophylline enhanced the production of glycerol by the tissue and this effect was not further augmented by epinephrine.”

“At initial concentrations of 0.1 and 1.0 M, glycerin and propylene glycol increase significantly the intestinal absorption rate of theophylline from the small intestine of anesthetized rats.”

“ Theophylline and DBcAMP increased glycerol release dose-dependently, while cAMP and ATP were ineffective up to I mM. Theophylline (0.4–0.8 mM) potentiated the lipolytic effect of nerve stimulation, while 2–8 mM apparently caused maximal stimulation Per se.”

“Summary Theophylline , at a concentration from 1.0–10.0 mM, significantly inhibited glucose production from glycerol , malate, pyruvate, and α-ketoglutarate by the isolated tubules of rat renal cortex; the higher the theophylline concentration in the incubation media the smaller the glucose production rates were.”