Possible Interaction: Glycerol and Sodium Dodecyl Sulfate

“To rationalize this important observation, which may also be related to the well-known beneficial effects … on skin barrier perturbation in vivo, we hypothesize that the addition of 10 wt% glycerol may hinder … of the SDS micelles to penetrate into the skin barrier … pores that exist in the SC.”

“…%glycerol: (… SDS contacting solution from 33 +/- 5 Angstrom to 20 +/- 5 Angstrom, such that a SDS micelle of radius 18.5 +/- 1 Angstrom (as determined using … by more than 50%, thereby further reducing the ability of the SDS micelles to penetrate into the SC and perturb the skin barrier.”

“Thus, glycerol appears to substitute for natural moisturizing factors that have been washed out by the detergent action of SLS , enhancing skin hydration but without restoring skin barrier function as depicted by TEWL values that remained high.”

“However, glycerol has shown anti-irritant properties in experimentally induced irritation from sodium lauryl sulfate and nonanoic acid (NON).”

“Electrophoretic analyses suggested that glycerol stabilized an active structure of the enzyme, and sodium dodecyl sulfate might dissociate it.”

“Through a quantification of the amount of SRB that penetrated into … as a function of skin depth, we found that adding glycerol … SDS aqueous contacting solution can significantly reduce the SDS-induced penetration depth of SRB, … evidence of the ability of glycerol to mitigate SDS-induced skin barrier perturbation.”

“Such SDS aggregation or gelation has not been observed in water at such low surfactant concentrations, whereas SDS has been reported to form lamellar aggregates in glycerol (a component of glyceline).”

“Overall the addition of glycerol increases the CMC and the TK, thus shifting the Krafft point of SDS to higher temperatures (increasing crystallisation temperatures) and higher SDS content in the presence of glycerol, which is interpreted as a result of the reduction in solvent polarity which opposes micellization.”

“The formation of these structures arises from the synergistic surface segregation of SDS and glycerol , evidenced by surface tensiometry.”

“Among different additives and detergents, polyethylene glycol 8000 and Tween 20, 40, and 80 stabilized the enzyme activity, whereas Triton X-100, glycerol , glycine, dextrin, and sodium dodecyl sulfate inhibited to a varied extent.”