Possible Interaction: Glycerol and Ribose

“A genetic screen for suppression of the growth defect of Escherichia coli tktA tktB mutant in LB medium revealed … rendered the glpK expression constitutive and another that inactivated deoB. Characterizing these mutations aided in uncovering the role of ribose‐5‐P (a transketolase … of glycerol assimilation and …‐P synthesis.”

“To our knowledge, this report is the first to show ribose‐5‐P can modulate glycerol‐3‐P concentration in the cell by regulation of glycerol assimilation as well as its de novo synthesis.”

“Using lacZ fusions, we show that ribose‐5‐P enhances GlpR–mediated repression of the glpFKX operon and inhibits glycerol assimilation.”

“On the addition of ribose to glycerol-adapted cells of B 525 preincubated in glycerol media , the intracellular K + decreased immediately and markedly.”