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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycerol
Research Papers that Mention the Interaction
“As co-surfactant, glycerol may intercalate within the polyoxyethylene chains of the surfactant at the palisade layer, increasing the interface flexibility and expanding it.”
Self-emulsification of Lipidic Drug Delivery System in Pure Water and in Concentrated Glycerol Solution“The addition of surfactant such as Tween 80 increased the GC conversion, which finally reached 96.25% under the optimum condition and with surfactant addition.”
“The addition of glycerol or PEG to the surfactant solutions had only a minor impact on the solubility.”
“For Brij 58, in spite of the lowering of the aggregation number, the surfactant intradiffusion coefficient decreases with increasing glycerol concentration, suggesting an increase of the intermicellar interaction.”
“In the case of Brij 58, the results can be interpreted in terms of a salting-out effect according to which glycerol competes with the surfactant for water molecules, causing a dehydration of the surfactant ethoxylic headgroup.”
“We found that glycerol increases the aggregation number and withdraws the hydrating agents from the headgroup region of the surfactant , resulting in a higher packing density of molecules in a micelle at slightly increasing size.”
“Evidence is presented for the detection of distonic radical cations of the surfactant , complexed (solvated) with glycerol.”
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