Possible Interaction: Glycerol and Propranolol

“Only propranolol produced a significant decrease (P < .05) in the rate of appearance of glycerol , from a mean (+/- SD) of 5.54 +/- 0.62 to 3.07 +/- 0.7 mumol/kg per minute.”

“ Propranolol reduced fasting glycerol and free fatty acid concentrations in both groups.”

“ Propranolol decreased the pulse rate (P less than 0.01) and the levels of serum triiodothyronine (T3; P less than 0.05), blood glycerol (P less than 0.01), and KB (P less than 0.01).”

“Apart from possible effects on hepatic glycogenolysis propranolol also inhibits the release of the important gluconeogenic substrates lactate and glycerol.”

“ Propranolol has been shown also to perturb glycerol transport in red cells.”

“Despite an identical exercise time, glycerol and NEFA concentrations during recovery were significantly lower after propranol treatment.”

“In hyperthyroid patients propranolol administration for 4 days induced a decrease in triiodothyronine (349±140 to 229±107 ng/100ml, p<0.01) and a dramatic fall in ketone body (18–295 μmol/l, p<0.001) and glycerol (44–130 μmol/l, p<0.001) levels.”

“A corresponding local beta-adrenoceptor blockade with propranolol (10−4 M), inhibited the increase in adipose glycerol levels by ∼60% (P=0.02).”

“The mechanism of the effect of propranolol is probably an attenuation of the gluconeogenesis secondary to deficient release of the important gluconeogenic substrates lactate and glycerol.”

“ Oral propranolol administration to hyperthyroid patients in the post-absorptive state decreased the concentrations of glycerol (p less than 0.05) and ketone bodies (p less than 0.05) without altering insulin concentrations.”