Possible Interaction: Glycerol and Nicotine

“Results Topics reviewed include e-liquid components or …), base e-liquid ingredients (propylene glycol, vegetable glycerin ), components commonly used to dissolve flavorants (e.g., ethanol), and resulting properties of the e-liquid (… characteristics (e.g., wattage, temperature, model) and user behavior (e.g., puff topography) which may impact nicotine ….”

“ Nicotine increased venous plasma glycerol levels by 144±9% (P<0.001), arterialized plasma glycerol levels by 148±12% (P<0.001) and adipose glycerol levels by 148±16% (P<0.001), but did not alter blood flow.”

“2 Addition of nicotine to the perfusion solvent caused a concentration‐dependent reversible increase in the levels of glycerol in the dialysate (lipolysis index).”

“ Nicotine caused a significant dose-dependent increase in the plasma levels of nicotine, cotinine, noradrenaline, adrenaline, glycerol and free fatty acids (FFA).”

“ Nicotine produced significant elevations of adrenaline, glycerol and FFA concentrations at both doses (maximal increments of 247, 184 and 153%, respectively) and the peak effect occurred at 30 min.”

“Serum noradrenaline, adrenaline, glycerol and FFA levels had increased significantly by 15 min of nicotine infusion.”

“Additionally, glutathione and taurine in hippocampus and striatum, phosphocholine in PFC and glycerol in NAc were significantly modified by nicotine , implying the dysregulation of anti-oxidative stress response and membrane metabolism.”

“On a tar basis, nicotine in smoke was significantly decreased at 10% and 15% glycerin while water was increased at all addition levels.”