Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“The mean dose required to reduce ICP below 15 mm Hg for 3% hypertonic saline: 1.4 mL/kg, for 10% mannitol plus 10% glycerine : 1.7 mL/kg, and for 20% mannitol: 2.0 mL/kg.”
“The duration of the therapeutic effect of glycerol (190 ± 41 min) was significantly longer (p < 0.01) than that of sorbitol (150 ± 28 min) or mannitol (130 ± 20 min).”
“Both peroral administration of glycerol and intravenous administration of mannitol lowered the interstitial fluid pressure of the facial nerve as well as the cerebrospinal fluid pressure.”
“Brain amino acids (mostly aliphatic and basic amino acids) as well as Gaba and glycine (putative inhibitory neurotransmitters) increased after both mannitol and glycerol.”