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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Glycerol and Mannitol



Research Papers that Mention the Interaction

The duration of the therapeutic effect of glycerol (190 +/- 41 min) was significantly longer (p < 0.01) than that of sorbitol (150 +/- 28 min) or mannitol (130 +/- 20 min).
European neurology  •  1998  |  View Paper
The mean dose required to reduce ICP below 15 mm Hg for 3% hypertonic saline: 1.4 mL/kg, for 10% mannitol plus 10% glycerine : 1.7 mL/kg, and for 20% mannitol: 2.0 mL/kg.
World neurosurgery  •  2019  |  View Paper
Combining Mannitol and Glycerol provides a better alternative and is currently available as best therapy used for increased ICP.
International journal of biomedical science : IJBS  •  2009  |  View Paper
Compared to PBS or glycerol , the administration of mannitol resulted in increased BBB disruption.
Neuroscience Letters  •  2013  |  View Paper
Both peroral administration of glycerol and intravenous administration of mannitol lowered the interstitial fluid pressure of the facial nerve as well as the cerebrospinal fluid pressure.
Acta oto-laryngologica  •  1990  |  View Paper
Brain amino acids (mostly aliphatic and basic amino acids) as well as Gaba and glycine (putative inhibitory neurotransmitters) increased after both mannitol and glycerol.
Brain Research  •  1981  |  View Paper
Mannitol and sorbitol improved the sperm motility at initial preservation phase, while glycerol at this phase depressed the motility.
Annales de recherches veterinaires. Annals of veterinary research  •  1980  |  View Paper