Possible Interaction: Glycerol and Isoproterenol

“RESULTS:… isoproterenol infusion, the increase in dialysate glycerol concentration was significantly 1.5-fold higher in the SGA than in the AGA group (P=0.02) and induced a 20% increase in the plasma FFA concentration (P=0.04), whereas no significant increase was observed in the AGA group.”

“ Blood glycerol concentration also increased with isoprenaline but blood lactate concentration was unaltered.”

“A nonselective beta-adrenoceptor agonist, isoprenaline , caused a concentration-dependent stimulation of glycerol release, whereas FFA release was unaffected.”

“ Glycerol release … μM isoprenaline , 1 mM isobutylmethylxanthine) while the amine was ineffective from 0.01 to 100 μM and hardly stimulatory at 1 mM. Tyramine exhibited a … similar to that of insulin but weaker than that obtained with agonists at purinergic A1 receptors, α2-adrenoceptors, or nicotinic acid receptors.”

“ Isoproterenol (ISO) significantly increases glycerol release in subcutaneous, omental and mesenteric adipose tissues of non diabetic subjects but it stimulated glycerol release was significantly impaired in all three fat depots of the diabetic subjects.”

“With isoprenaline , the cAMP concentration and the glycerol production was significantly higher in the diabetic adipose tissue.”

“We found an almost complete overlap in dialysate glycerol concentrations during isoproterenol stimulation between PAF and MSA patients and healthy young control subjects.”

“ Glycerol … isoproterenol was significantly higher in fat cells from the 10 CC carriers than in adipocytes from the T allele carriers when expressed as percentage of … carriers: 247 +/- 88 %, p = 0.01), while basal glycerol concentrations were no different according to genotype after controlling for either age or BMI.”

“Infusion of the beta-adrenergic agonist, isoproterenol , induced an increase in plasma levels of nonesterified fatty acids and glycerol that was more pronounced during than before VLCD.”

“Isoprenaline infusion at 0.… while higher concentrations of isoprenaline (0.1 and 1 … concentration-dependent increase of glycerol outflow; the maximum increase was 306 +/- 34% with 1 microM. Isoprenaline also increased the nutritive blood … significant effect appeared at 0.1 microM isoprenaline and was greater at 1 microM. 4.”