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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glycerol
drug:
Gentamicin
Research Papers that Mention the Interaction
“In other in vitro studies, we demonstrated that gentamicin depressed the permeability of phosphatidylcholine (PC)/PI liposomes to glycerol and promoted liposomal aggregation.”
Polyaspartic acid inhibits gentamicin-induced perturbations of phospholipid metabolism.“ Gentamicin caused a temperature-dependent decrease of p and raised Ea for glycerol permeation from 17.7 +/- 0.3 to 21.6 +/- 0.4 kcal/mol in PC-PA liposomes but had little or no effect on these parameters in PC-PA* liposomes.”
“We previously reported that gentamicin binds to liposomes composed of anionic phospholipids and depresses glycerol permeability and raises the activation energy for glycerol permeation in these liposomes.”
The effect of gentamicin on the biophysical properties of phosphatidic acid liposomes is influenced by the O-C = O group of the lipid.
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