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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycerol
drug:
Clavulanic Acid
Research Papers that Mention the Interaction
“It is known that glycerol utilization can significantly improve cell growth and CA production of S. clavuligerus.”
Enhanced production of Clavulanic acid by improving glycerol utilization using reporter-guided mutagenesis of an industrial Streptomyces clavuligerus strain.“While clavulanic acid accumulated at glycerol excess, it steadily decreased at declining dilution rates; CA synthesis stopped when glycerol became the limiting substrate.”
“The addition of glycerol or other vegetable oils (e.g., olive oil, corn oil) could potentially affect clavulanic acid production.”
“ Clavulanic acid production was increased by 18% with the span of feeding glycerol and reached a maximum at 1.30mg/ml with 120h glycerol feeding as compared to 1.10mg/ml in the control.”
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