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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycerol
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“Gluconeogenesis from combinations of glycerol together with either lactate, pyruvate, 2-oxoglutarate or malate was appreciably greater than the sum of the glucose output observed when these substrates were added singly.”
Gluconeogenesis in guinea pig renal tubule fragments--effects of noradrenaline, 3':5' cyclic AMP and angiotensin II.“… glycerol in the medium, the activity of … at the key node of 2-oxoglutarate was depressed, more carbon flux distribution was directed to synthesize glutamate, the substrate of γ-PGA, which led … γ-PGA, reached 31.7 g/l, compared to the original value of 26.7 g/l.”
Improvement of poly(γ-glutamic acid) biosynthesis and redistribution of metabolic flux with the presence of different additives in Bacillus subtilis CGMCC 0833“ 2-Ketoglutarate --unlike any other derivative of the citric acid cycle--was found to strongly repress catabolite-sensitive genes, such as the lactose operon (lac) or the tryptophanase gene (tna), when added to cells grown in glycerol.”
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