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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Glycerol and Adenosylcobalamin

Research Papers that Mention the Interaction

Coenzyme B12-dependent glycerol dehydratase (GDHt) catalyzes the dehydration reaction of glycerol in the presence of adenosylcobalamin to yield 3-hydroxypropanal (3-HPA), which can be converted biologically to versatile platform chemicals such as 1,3-propanediol and 3-hydroxypropionic acid.
Frontiers in Bioengineering and Biotechnology  •  2020  |  View Paper
It requires coenzyme B12 for catalytic activity and is subject to suicide inactivation by glycerol during catalysis.
Biotechnology Letters  •  2013  |  View Paper
The diol dehydratase was inhibited by various corrinoids adenosylcobalamin , cyanocobalamin, hydroxocobalamin, and methylcobalamin) by up to 37% at a concentration of 100 muM. Changes in ionic strength and the K ion concentration had only limited effects on this enzyme activity; glycerol inhibited the enzyme by 95%.
The diol dehydratase was inhibited by various corrinoids adenosylcobalamin , cyanocobalamin, hydroxocobalamin, and methylcobalamin) by up to 37% at a concentration of 100 μM. Changes in ionic strength and the K+ ion concentration had only limited effects on this enzyme activity; glycerol inhibited the enzyme by 95%.
Applied and environmental microbiology  •  1992  |  View Paper