supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Glycerol
drug:
Adenosylcobalamin
Research Papers that Mention the Interaction
“Coenzyme B12-dependent glycerol dehydratase (GDHt) catalyzes the dehydration reaction of glycerol in the presence of adenosylcobalamin to yield 3-hydroxypropanal (3-HPA), which can be converted biologically to versatile platform chemicals such as 1,3-propanediol and 3-hydroxypropionic acid.”
Recent Progress in the Understanding and Engineering of Coenzyme B12-Dependent Glycerol Dehydratase“It requires coenzyme B12 for catalytic activity and is subject to suicide inactivation by glycerol during catalysis.”
“The diol dehydratase was inhibited by various corrinoids adenosylcobalamin , cyanocobalamin, hydroxocobalamin, and methylcobalamin) by up to 37% at a concentration of 100 muM. Changes in ionic strength and the K ion concentration had only limited effects on this enzyme activity; glycerol inhibited the enzyme by 95%.”
“The diol dehydratase was inhibited by various corrinoids adenosylcobalamin , cyanocobalamin, hydroxocobalamin, and methylcobalamin) by up to 37% at a concentration of 100 μM. Changes in ionic strength and the K+ ion concentration had only limited effects on this enzyme activity; glycerol inhibited the enzyme by 95%.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback