Possible Interaction: Glycerol and Acipimox

“The rise in plasma free fatty acids and glycerol was almost totally prevented by Acipimox , and no significant rise in the utilization of lipids, evaluated by indirect calorimetry, was observed.”

“ Acipimox treatment, produced significantly lower fat oxidation (36.9 +/- 12.8% vs 50.2 +/- 16.1%, P = 0.011), and lower plasma concentrations of FFA and glycerol (P = < 0.0001 and P = < 0.0001, respectively).”

“After administration of acipimox , lipolysis was inhibited as reflected by lower plasma non-esterified fatty acid (0.05 +/- 0.02 versus 0.55 +/- 0.05 mmol/l, P less than 0.001) and blood glycerol (8 +/- 1 versus 56 +/- 8 mumol/l, P less than 0.001) concentrations.”

“These data indicate that met-GH induces lipolysis in man, increasing both FFA and glycerol levels, and that ACX blocks these effects.”

“In submaximally stimulated adipose tissue (isoprenaline 10(-7) mol/l) acipimox (10(-4) mol/l) fully inhibited release of fatty acids (P less than 0.05) and glycerol (P less than 0.025) to basal rates.”

“In unstimulated adipose tissue acipimox (10(-3) mol/l) reduced the rate of glycerol release (P less than 0.05), but not the rate of fatty acid release.”

“The release of fatty acids and glycerol from adipose tissue maximally stimulated by isoprenaline (10(-5) mol/l) fell by 40 and 25% respectively (P less than 0.025 and P less than 0.025) in the presence of acipimox (10(-5) mol/l).”

“Glycogen synthesis from glycerol tended to decrease when lipolysis was suppressed by acipimox , although the statistical significance of this effect was marginal.”

“ Acipimox (Aci) inhibits lipolysis in AT and reduces plasma glycerol and free fatty acid (FFA) levels.”