Possible Interaction: Glyburide and Taurine

“Incubation of endothelium-denuded CC strips with the nonselective …/l), the ATP-sensitive potassium (KATP) channel blocker glibenclamide (10 μmol/l), the inward rectifier potassium (Kir) channel inhibitor barium chloride (30 μmol/l), …-activated potassium channel inhibitor iberiotoxin (0.1 μmol/l) significantly inhibited the relaxant responses to taurine.”

“The relaxant effect of taurine was significantly inhibited by pretreatment of endothelium-denuded aorta with potassium channel antagonists glibenclamide and tetraethylamine but not by BaCl2 or 4-aminopyridine.”

“ Glybenclamide elicited a greater increase in [Ca(2+)](c) and increased insulin secretion in the beta-cells when pretreated with taurine.”

“The sensitivity of the K(ATP) channel to glybenclamide , but not gliclazide, was enhanced by taurine.”

“ Taurine at the concentration of 10 mM enhanced the high-affinity bindings of glibenclamide and repaglinide on all types of SUR, whereas the low-affinity binding on Kir6.2 was not affected.”

“Competition experiments showed that taurine shifted the dose‐response inhibition curve of glybenclamide to the left on the log‐dose axis without significantly affecting those of ATP or Ca2+ ion.”

“Our data indicate that taurine inhibits the muscular KATP channel interfering with the glybenclamide site on the sulphonylurea receptor of the channel or on the site allosterically coupled to it.”