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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glyburide
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“The 1.0- and 3.0-g doses of sodium bicarbonate also increased the AUC of plasma glibenclamide from 0 to 2 h, about 3-fold (p = 0.05 and 0.07, respectively).”
The effects of different doses of sodium bicarbonate on the absorption and activity of non-micronized glibenclamide.“It has been observed that in case of magnesium oxide, magnesium trisilicate and sodium bicarbonate , availability of glibenclamide was enhanced while in rest of the antacids retarded the availability of glibenclamide.”
In vitro availability of glibenclamide in presence of antacids.“Simultaneously administered magnesium hydroxide or sodium bicarbonate can increase the rate and extent of absorption of non‐micronized glibenclamide and glipizide.”
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