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Last Updated: 2 years ago

Possible Interaction: Glyburide and Oxytocin

supplement:

Oxytocin

Research Papers that Mention the Interaction

Since oxytocin's effects during the early phase were also antagonized by Nω-nitro-l-arginine methyl ester, ODQ, or glibenclamide (inhibitors of nitric oxide synthase [NOS], soluble guanylyl cyclase [GC], and K+ATP channels, respectively), the role of two differential pathways elicited by oxytocin is supported.
ACS chemical neuroscience  •  2021  |  View Paper
Inactivating K ATP channels with 200 nM glibenclamide increased oxytocin and vasopressin release (OT: P < 0.003; VP: P < 0.05).
American journal of physiology. Regulatory, integrative and comparative physiology  •  2014  |  View Paper
Glibenclamide , a selective blocker of adenosine triphosphate (ATP)-sensitive K(+) (K(ATP)) channels, antagonized the pinacidil-induced inhibition of contractions elicited by oxytocin in a competitive manner.
Basic & clinical pharmacology & toxicology  •  2007  |  View Paper