Possible Interaction: Glyburide and Glutathione

“Furthermore, glibenclamide treatment reduced the contents of malondialdehyde (MDA) as well as elevated glutathione (GSH) levels and total-antioxidative capacity in the spinal cord of HD-intoxicated rats, indicating attenuated oxidative stress.”

“Treatment with either naringin or glibenclamide significantly reduced lipid peroxidation, Superoxide Dismutase (SOD) activities and also increased glutathione (GSH) and ATP levels in the cells that were treated with PIs.”

“Administration of bacosine and glibenclamide significantly decreased the levels of malondialdehyde (MDA), and increased the levels of reduced glutathione ( GSH ) and the activities of superoxide dismutase (SOD) and catalase (CAT) in the liver of diabetic rats.”

“ Glibenclamide and tolbutamide reduced the MPP+-induced cell death and GSH depletion concentration dependently with a maximal inhibitory effect at 5-10 microM. Despite the toxic effect at 20 microM, sulfonylureas showed an inhibitory effect.”

“Administration of glyburide to diabetic rats reversed the diabetes-induced changes suggesting that glyburide may directly increase liver glutathione concentrations.”

“In isolated perfused rat livers, infusion of the sulfonylureas, glyburide (2.5 microM) and tolbutamide (0.5 mM), stimulated by 2-fold the rate of biliary glutathione secretion.”

“In the endothelium-denude preparations, only glibenclamide inhibited the modulating effect of GSH on aortic tension.”

“The vasorelaxant effect of GSH in endotheliumintact rings was inhibited by glibenclamide (3 μM), methylene blue (10 μM) and N-nitro-L-arginine methyl ester (10 μM), indicating the involvement of membrane K+ channels and NO-cGMP pathway.”

“Transport of glutathione conjugates into plant but not into yeast vacuoles was drastically reduced by glibenclamide.”