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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glyburide
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“On the other hand, glybenclamide (3 mg/kg, ip), an ATP-sensitive K+ channel blocker, can also significantly reduce the antitussive effect of Ver— CA.”
Synthesis and antitussive evaluation of verticinone-cholic acid salt, a novel and potential cough therapeutic agent“These results indicate that glibenclamide increases [Na+i] by inhibiting the Na+-K+ pump and decreases contraction and Ca2+ transient, in addition, by blocking the L-type Ca2+ channel.”
“The insulinogenic effect of glibenclamide at 0.64 and 0.25 mmol/1 calcium was enhanced by 35% and 89%, respectively, compared to the response at 2.75 mmol/1 calcium.”
“ Glibenclamide (≥5 μm) also reduced calcium loading of the intracellular store, and enhanced calcium release.”
“The present observations suggest that glyburide promotes calcium influx via voltage-dependent calcium channels and may mobilize intracellular calcium stores.”
“ Glibenclamide (100 µM) also inhibited the increase in Ca2+ (74.7 ± 10.6 AU at the beginning and 71.8 ± 10.9 AU at the end of the experiment; n = 13; P = 0.851.”
A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels
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