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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glyburide
supplement:
Biochanin A
Research Papers that Mention the Interaction
“ Glibenclamide (3 x 10(-6) mol/L), a selective inhibitor of ATP-sensitive potassium channels, and tetraethylammonium (5 … 10(-3) mol/L), a Ca2+ -activated K+ channel inhibitor, significantly attenuated the relaxation induced by biochanin A. The vasoconstriction induced by phenylephrine was … by biochanin A in Ca2+ -free medium.”
[Endothelium-independent vasorelaxation of plant-derived estrogen biochanin A and its mechanism in rat aortic rings].“ Glibenclamide , a selective inhibitor of ATP‐sensitive potassium channels, significantly attenuated the relaxation induced by biochanin A in aortic rings from both strains, although the extent of reduction was greater in WKY rats than SHR.”
“By contrast, treatment with glibenclamide , a selective inhibitor of adenosine triphosphate-sensitive K+ channels, or tetraethylammonium, an inhibitor of Ca2+-activated K+ channels, significantly reduced biochanin A-induced relaxation in aortic rings from both groups.”
“The relaxant effect of biochanin A was significantly inhibited by pretreatment with the K+ channel antagonists tetraethylammonium and glibenclamide in endothelium-denuded aorta.”
Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta
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