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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glyburide
supplement:
Andrographolide
Research Papers that Mention the Interaction
“In conclusion, add‐on preparations containing BA or AD may increase the bioavailability of glyburide , and hence the dose should be monitored.”
“In normal and diabetic rats, the combination of glyburide with BA or AD increased significantly (p < 0.01) all the pharmacokinetic parameters, such as Cmax, AUC0–n, AUCtotal, t1/2, and mean residence time, and decreased the clearance, Vd, markedly as compared with the control group.”
“The increase in hypoglycemic action by concomitant administration of glyburide with BA or AD was more in diabetic rats than when the drugs were used singly and with the control group, which suggests the enhancement of glucose reduction capacity of glyburide in diabetic rats along with BA or AD.”
Pharmacokinetic and Pharmacodynamic Interaction of Boswellic Acids and Andrographolide with Glyburide in Diabetic Rats: Including Its PK/PD Modeling
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