Possible Interaction: Glutathione and Vitamin C

“Despite a strong positive correlation between ascorbic acid and glutathione levels , no other correlations among oxidative stress measures or post mortem interval were observed.”

“These results suggest a new role for high concentrations of vitamin C in modulation of intracellular sulfur containing compounds, such as glutathione and cysteine.”

“Treatment of cells with high doses of vitamin C resulted in an immediate increase in intracellular total glutathione content and glutathione-S transferase activity that was accompanied by the uptake of cysteine.”

“Although there is in vivo evidence suggesting a role for glutathione in the metabolism and tissue distribution of vitamin C , no connection with the vitamin C transport systems has been reported.”

“There is an antagonism between ascorbate and glutathione in treating cancer, and therefore iv AA and iv GSH should not be coadministered to cancer patients on the same day.”

“These data confirm the pro-oxidative anti-cancer mechanism of pharmacologic AA and suggest that AA and GSH administered together provide no additional benefit compared with AA alone.”

“ GSH can be reduced using agents such as buthionine sulfoximine (BSO) and ascorbic acid.”

“The oxidation of ascorbic acid in the presence of haemin was stimulated by GSH, suggesting that ascorbic acid can alter the mechanism of H(2)O(2) generation observed with GSH and haemin alone.”

“ Ascorbic acid and buthionine sulfoxide (BSO) decreased GSH to a greater extent, and rendered malignant cells more sensitive to As2O3.”

“Addition of glutathione (GSH) plus AA further diminished the covalent binding with concomitant increased formation of the GSH-conjugated epoxide.”

“Indeed, the … capacity of glutathione … ascorbic acid , whether singly or in combination, linked via the redox couple, is a subject of intense interest for studies by bench scientists and clinicians, particularly because a growing body of evidence suggests that free radicals may be involved in a variety of diseases.”

“ Ascorbic acid incubation markedly enhanced the occurrence of copper acetate-induced increases in METHB and decreases in GSH in the sheep and humans.”