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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Vincristine
Research Papers that Mention the Interaction
“In addition, vincristine accumulation was significantly modulated by altering the intracellular concentration of the reduced form of glutathione , further suggesting the involvement of rMRP1-mediated transport.”
Functional Expression of the Multidrug Resistance Protein 1 in Microglia“LTC4 uptake was also markedly reduced by the competitive inhibitor,S-decyl-glutathione, as well as by the MRP1 substrates 17β-estradiol 17-β-(d-glucuronide), oxidized glutathione, and vincristine in the presence of reduced glutathione.”
“At least 90% of the ATP-dependent uptake was blockable by the anti-MRP1 antibody QCRL-3 and 100 microM vincristine inhibited uptake but only in the presence of 1--3 mM GSH , suggesting MRP1 to be the protein primarily responsible for this transport.”
“However, treatment with etoposide or vincristine (at similar molar concentrations) caused a 20% decrease in glutathione.”
“Taxol, VP-16, vincristine , and vinblastine were also poor inhibitors of LTC4 transport but inhibition by these compounds was enhanced by GSH.”
“ Vincristine decreased cellular GSH concentration and increased GPx activity.”
Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine
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