Possible Interaction: Glutathione and Ursodeoxycholate

“ Ursodeoxycholic acid , melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs.”

“ConclusionThus, changes in GSH levels with exogenous agents such as NAC, UDCA , BSO or DEM modulate hyperglycemia-mediated injury in a cell model of VL-17A liver cells.”

“In conclusion, modulation of GSH with NAC or UDCA or BSO or DEM leads to significant changes in oxidative stress, glyoxalase 1 enzyme activity and toxicity in chronic alcohol plus high glucose treated VL-17A cells.”

“From these results, it was indicated that UDCA increased the GSH synthesis through an activation of the PI3K/Akt/Nrf2 pathway.”

“ UDCA inhibited both a decrease in the GSH level and an increase in the reactive oxygen species caused by excessive iron in the cells.”

“ UDCA and SAMe induced the expression of GCL subunits and raised GSH levels.”

“Moreover, pretreatment with UDCA normalized the GSH level and inhibited the elevation in hepatic MDA concentration.”

“In conclusion, UDCA treatment enhances the antioxidant defense mediated by glutathione ; in doing so, this treatment prevents cardiolipin depletion and cell injury in animals with secondary biliary cirrhosis. (”

“Conclusions: Ursodeoxycholate specifically enhanced methionine adenosyltransferase activity and hepatic glutathione levels.”

“Results: We found that in livers perfused with ursodeoxycholate , levels of glutathione and the activity of methionine adenosyltransferase (an enzyme involved in glutathione biosynthesis) were significantly higher than in livers perfused with other bile salts.”

“In conclusion, UDCA increased hepatocyte levels of GSH and thiol-containing proteins such as MT, thereby protecting hepatocytes against oxidative injury.”

“Reduced glutathione GSH ) levels tended to slightly decrease with UDCA diets but the difference did not attain a statistical significance (P > 0.05, one-way ANOVA).”