Possible Interaction: Glutathione and Urea

“Compared with diabetic control group, administration of 320 mg/kg SAT resulted …) fall in the levels of fasting blood glucose, glycosylated hemoglobin, creatinine, urea , alanine transarninase, aspartate aminotransferase, total cholesterol, triglycerides, low density lipoprotein cholesterol and ….05) increase in the levels of serum insulin, superoxide dismutase and reduced glutathione.”

“The presence of glutathione caused a shift in the equilibrium‐unfolding curves towards lower urea concentrations and enhanced the first‐order rate constant for unfolding suggesting a destabilisation of the pGSTP1‐1 structure against urea.”

“Combined effects of urea and ionic strength on the reaction of GSH and of histone H3 with Nbs 2 gives rise to shifts of both curves of K 2(app) us.”

“The average values of urea and creatinine were significantly lower in the group treated with GSH (115 vs 370 mg/dl and 1.07 vs 4.02 mg/dl respectively).”

“ GSH , but not GSSG, inhibits the reactivation by phosphate ion of ribonuclease activity inactivated by urea or guanidine.”

“The effects of GSH are rather slow and pretreatment of ribonuclease with urea is a requisite for the inhibitory action of GSH on enzyme reactivation.”