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Last Updated: 2 years ago

Possible Interaction: Glutathione and Tyrosine

supplement:

Glutathione

supplement:

Tyrosine

Research Papers that Mention the Interaction

We observed that the inhibition caused by tyrosine was concentration-dependent and was prevented by reduced glutathione.
Metabolic Brain Disease  •  2011  |  View Paper
A consistent feature of the Alpha-, Mu- and Pi-class glutathione transferases (GSTs) is the presence near the N-terminus of a tyrosine residue that contributes to the activation of glutathione.
The Biochemical journal  •  1995  |  View Paper
The increased tyrosine radicals can be reduced by endogenic antioxidants such as GSH.
Biochimica et biophysica acta  •  2014  |  View Paper
Complete inhibition of tyrosine phosphorylation was noticed when cells were stimulated in the presence of N-acetylcysteine or glutathione.
The Journal of investigative dermatology  •  2003  |  View Paper
GSH concentration in newly collected plasma from day … to 115 microM, while the titer of tyrosine , a substrate for the PO cascade, was 141 microM. GSH titers rapidly declined in …, but no melanin formation occurred until GSH levels fell below 20 microM. Added GSH dose-dependently blocked … GSH inhibition.
Insect biochemistry and molecular biology  •  2010  |  View Paper
These results indicate that tyrosine 9 is directly responsible for the lowering of the pKa of the sulfhydryl group of glutathione , presumably due to the stabilization of the thiolate anion through hydrogen bonding with the hydroxyl group of tyrosine.
The Journal of biological chemistry  •  1992  |  View Paper
In contrast, Cu tyrosine causes a slight drop in GSH in starved animals.
Research communications in chemical pathology and pharmacology  •  1982  |  View Paper
Glutathione , serotonin and synthetic sulfur- and selenium-containing compounds inhibited both the nitration and oxidation reaction of L-tyrosine effectively.
Chemical & pharmaceutical bulletin  •  2000  |  View Paper
Glutathione and synthetic compounds ((2S,3R,4S)-N-ethylmercapto-3,4-dihydroxy-2-hydroxymethylpyrrolidine, L-N-dithiocarboxyproline) inhibited both the nitration and the oxidation reactions of L-tyrosine effectively.
Antioxidants & redox signaling  •  1999  |  View Paper
In addition, glutathione has been shown to activate at least one step in tyrosine oxidation , and the indications were that still another labile cofactor for which low concentrations of 2,6-dichlorophenol indophenol could substitute was involved in the system.
The Journal of biological chemistry  •  1953  |  View Paper