Possible Interaction: Glutathione and Triiodothyronine

“Reduced glutathione content (RG) was reduced in the period T3.”

“The changes observed in the levels of GSH and GSSG and its metabolizing enzymes in response to T3 treatment reflect an alteration in the redox state of testis, which may be a causative factor for the impairment of testicular physiology as a consequence of oxidative stress.”

“In this study, T3 administration in rats (single dose of 0.1 mg/kg intraperitoneally) induced significant depletion of reduced liver glutathione (GSH), with higher protein oxidation, O2 consumption, and Kupffer cell function (carbon phagocytosis and carbon‐induced O2 uptake).”

“ T3 in vitro (10(-6) M) increased the antioxidant activities of catalase, glutathione reductase (GR), GPx and glutathione level after 15/30 min, except SOD, substantiating in vivo effects in normal fish.”

“ T3 treatment induced a significant 56% depletion of liver GSH in parallel with an increase in the rate of GSH synthesis, the latter effect being completely abolished by L-buthionine sulfoximine.”

“Both the thioredoxin system (thioredoxin, thioredoxin reductase, and NADPH) and the glutaredoxin system (glutaredoxin, glutathione reductase, glutathione , and NADPH) increased specific binding of T3 to nuclei, solubilized receptor, and chromatographed receptor significantly.”

“However, basal rates of microsomal oxygen uptake and light emission in liver homogenates and microsomes were decreased by t-BHP, probably related to thyroid … content of cytochrome P-450 (Fernández et al.) In addition, liver superoxide dismutase and catalase activities as well as the total content of glutathione … T3.”

“There was a significant decrease in glutathione to 1.48 (±0.06) mg/g liver 24 hours after T3 administration (1 mg/kg subcutaneously for five days), but no further decrease with continued T3 pretreatment or with halothane anesthesia.”

“A significant difference in alpha glutathione S‐transferase concentration between the two groups was found at t2 and t3.”