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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Topiramate
Research Papers that Mention the Interaction
“Moreover, after inducing testicular T/D, GPx, CAT and SOD activity were decreased, whereas administration of TPM significantly increased GSH level and GPx, CAT and SOD activities and decreased MDA level in testis tissue as compared to T/D group.”
Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion.“In addition, TPM treatment increased BDNF gene and protein expressions, Bcl‐2 expression, the level of reduced form of glutathione (GSH) and activities of enzymes superoxide dismutase, glutathione peroxidase and glutathione reductase.”
“ TPM (70 and 100 mg/kg) reduced MPH‐induced rise in lipid peroxidation, oxidized form of glutathione (GSSG), IL‐1&bgr; and TNF‐&agr; levels, Bax expression and motor activity disturbances.”
“In addition, TPM treatment increased Bcl-2 expression, the level of reduced form of glutathione (GSH) and the levels and activities of superoxide dismutase, glutathione peroxidase and glutathione reductase enzymes.”
“ TPM (70 and 100 mg/kg) reduced MPH-induced rise in lipid peroxidation, oxidized form of glutathione (GSSG), IL-1β and TNF-α levels, Bax expression and motor activity disturbances.”
“ TPM modulated also lipid peroxidation and glutathione and vitamin C concentrations in the cell system.”
“… glutathion … TPM group (29.85 +/- 1.62 mg/g prot) or in the TPM plus VPA group (29.63 +/- 4.47 mg/g prot) were significantly … mg/g prot) and that of the low dosage of TPM group (32.43 +/- 2.11 mg/g prot) (both P < 0.05).”
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