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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Tolbutamide
Research Papers that Mention the Interaction
“Glibenclamide and tolbutamide reduced the MPP+-induced cell death and GSH depletion concentration dependently with a maximal inhibitory effect at 5-10 microM. Despite the toxic effect at 20 microM, sulfonylureas showed an inhibitory effect.”
Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide.“It is also suggested that GSH and L-cysteine increase the sensitivity of β-cells to the stimulatory action of tolbutamide and/or glucose.”
“At critical periods of organogenesis, the resulting perturbation of GSH homeostasis in exposed tissues may play a key role in the teratogenic and/or embryotoxic effects of TOLB.”
“It has been proposed that the teratogenic effects of TOLB are linked to drug-mediated depletion of glutathione (GSH) through inhibition of the enzyme glutathione reductase (GR), although the mechanism by which this inhibition occurs remains unknown.”
“In isolated perfused rat livers, infusion of the sulfonylureas, glyburide (2.5 microM) and tolbutamide (0.5 mM), stimulated by 2-fold the rate of biliary glutathione secretion.”
“Perfusion of the liver in situ with insulin or sulphadiazine did not alter its GSH content but perfusion with tolbutamide significantly reduced the GSH content.”
“The blood reduced glutathione GSH ) concentration of normal rats was reduced by the intra-cardiac injection of tolbutamide but not by insulin or sulphadiazine.”
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