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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Glutathione and Tissue Plasminogen Activator

Research Papers that Mention the Interaction

As free radical scavenger, GSH could react with tri-n-propylamine radical (i.e. TPA+• ) and effectively suppress the excitation of Ru(bpy)32+, thus made the ECL signal significantly decrease.
Talanta  •  2019  |  View Paper
A single topical application of TPA caused significant depletion in reduced glutathione (GSH) content, activities of its metabolizing and antioxidant enzymes, while malondialdehyde (MDA) formation, H2O2 content, ornithine decarboxylase (ODC) activity and DNA synthesis were significantly increased.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation  •  2004  |  View Paper
TPA treatment in non-iron-treated mice … in approximately 20-40% decrease in GSH level and in the activities of antioxidant enzymes, whereas 1.5-mg iron treatment along with TPA treatment resulted in about approximately 30-70% decrease in GSH level and in the activities of antioxidant enzymes.
Archives of biochemistry and biophysics  •  2003  |  View Paper
Similarly, TPA treatment in photosensitized animals augmented the depletion of cutaneous glutathione and enhancement of lipid peroxidation.
Cancer letters  •  1999  |  View Paper
In vitro, various treatments with 1 mM GSH , 1 mM glutamic acid (Glu), 1 mM glycine (Gly), 0.4 mM Cys and/or 0.2 mM cystine (CysCys) inhibited dramatically the sharp decline in the intracellular ratio of GSH/GSSG caused by 0.1 microM TPA.
Carcinogenesis  •  1985  |  View Paper
The production of tPA in the serum-free and low-serum media with VCP (0.282, 2.92 mg/l) or GSH (1.01, 1.61 mg/l) was markedly higher than that in the cultures without the antioxidants (0.275, 0.689 mg/l).
Journal of bioscience and bioengineering  •  2001  |  View Paper