supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Glutathione
drug:
Ticrynafen
Research Papers that Mention the Interaction
“Covalent binding of TA metabolites to microsomal proteins occurred in parallel with enzyme inactivation and was partially inhibited by the presence of glutathione in the reaction medium.”
Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.“Both covalent binding of TA and TAI metabolites are almost completely suppressed in the presence of glutathione.”
“… tienilic acid … GSH level and upregulated genes responsive to oxidative/electrophilic stresses, such as heme oxygenase-1 (Ho-1), glutamate-cysteine ligase modifier subunit (Gclm) and … (Nqo1), in rat liver, as well as inducing hepatotoxicity by co-treatment with the glutathione biosynthesis inhibitor l-buthionine-(S,R)-sulfoximine (BSO).”
Involvement of cytochrome P450-mediated metabolism in tienilic acid hepatotoxicity in rats.“The hepatic reduced glutathione level decreased at 3-6 h, and then increased at 24 or 48 … that the upregulation of NF-E2-related factor 2 (Nrf2)-regulated gene and the late increase in hepatic glutathione are protective responses against the oxidative …/or electrophilic stresses caused by tienilic acid.”
“Covalent binding of TAI , as that of TA, depends on cytochrome P-450-dependent monooxygenases and is almost completely inhibited in the presence of sulfur containing nucleophiles such as glutathione , cysteine or cyteamine.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback