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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Thyroxine
Research Papers that Mention the Interaction
“ T4 increased the level of oxidized form of glutathione , whereas the intracellular level of the reduced form decreased.”
A possible competition between 5'-monodeiodination of thyroxine and the respiratory burst in human granulocytes.“MDA, GSH , NO•x, IL-10, and TNF-alpha levels increased after L-thyroxine induction.”
The Interaction of Oxidative Stress Response with Cytokines in the Thyrotoxic Rat: Is There a Link?“An increase in lipid peroxidation (around 40%), and a decrease in total glutathione (by 20%) was induced by thyroxine and avoided by vitamin E administration.”
“The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH , GSH-Px and SOD levels of erythrocytes.”
“ T4 at dosage of 0.1 mg.kg-1/d for 3 weeks decreased GSH content in epididymides in rats.”
“Bilirubin, thyroxine , lithocholic acid, retinoic acid and retinol are competitive inhibitors with respect to glutathione.”
“Certain neurotransmitters, hormones, and drugs, such as serotonin, dopamine, glucocorticoids, thyroxine , apomorphine, and benzodiazepine derivatives, are effective inhibitors of brain glutathione transferase activity.”
“Liver GSH contents were lowered about 55% by both fasting and T4 while GSH transferase activities were lowered about 20% by fasting and 35% by T4.”
“In contrast, anaerobiosis and GSH inhibited ether-link cleavage of T4 , but facilitated T3 neogenesis.”
“ GSH levels were lower in lungs of rats pretreated with levothyroxine (16.7 mg/kg/day), which produced an accelerated development of pulmonary oxygen toxicity.”
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