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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Thiotepa
Research Papers that Mention the Interaction
“In the presence of glutathione , the rate of disappearance of thiotepa increased greatly (t1/2 = 282 min).”
The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.“While glutathione had little or no effect on the cytotoxicity of thio-TEPA or TEPA, low levels of extracellular glutathione (0.25-0.5 mM) fully blocked S9-dependent thio-TEPA activation, suggesting a cell surface site of action of the S9-generated cytotoxic metabolites.”
Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450.
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