Possible Interaction: Glutathione and Theanine

“Moreover, theanine inhibited GSH reduction induced by DOX in the liver and heart.”

“The reduction in the concentration of glutamate in tumor cells caused by theanine induced decreases in the intracellular glutathione ( GSH ) and GS-DOX conjugate levels.”

“Moreover, co-administration of Cystine and Theanine to rats significantly increased the glutathione level in the sciatic nerve compared with the oxaliplatin group.”

“Background and Aim: Oral administration of cystine and theanine (CT) may modulate antioxidant glutathione ( GSH ) metabolism, thereby improving outcomes after gut ischemia reperfusion.”

“Results Compared to the H2O2 treatment, all doses of L-theanine treatments increased the cell viability, glutathione level, and the activities of glutathione peroxidase and superoxide dismutase (P<0.001).”

“ l-Theanine also decreased the levels of malondialdehyde (MDA) and ROS, and obviously elevated the levels of glutathione (GSH) and activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the mouse brain.”

“The results of the present study suggest that pretreatment with L-theanine significantly attenuated 3-NP induced oxidative stress and restored the decreased SOD, GSH , CAT and SDH activity.”

“ l-Theanine also significantly reduced oxidative protein and lipid damage and the elevation of glutathione levels in the brain.”

“In conclusion, it appeared that theanine does not change the biodistribution of combined drugs but it modulates biodistribution or damage to the relative site of GSH , and shows preventive effects in tissue.”

“Cell uptake indicated that the presence of theanine can effectively inhibit glutathione (GSH) levels in cells and increase the uptake of DOX.”