Possible Interaction: Glutathione and Tempol

“Further … Tempol concentrations of 100–1000 μM induced an oxidant stress was that it caused an increase in the oxidation of dihydrofluorescein in cells … ascorbate transport at concentrations as low as 50–100 μM. The presence of intracellular ascorbate both prevented dihydrofluorescein oxidation and spared GSH from oxidation … Tempol.”

“ TPL was also observed to induce a cell-type specific decrease in GSH levels and in GSH-related enzyme activities that could contribute to its sensitizing effect.”

“A correlation between GSH levels and Tempol reduction rate was observed.”

“ Tempol significantly elevated kidney glutathione ( GSH ) content and SOD activity, and decreased kidney lipid peroxidation and NOx production.”

“In addition, tempol significantly ameliorated CCl4-induced lipid peroxidation and GSH depletion, and improved catalase activity.”

“However, Tempol treatment led to a statistically significant increase in anastomotic bursting pressure values, tissue HP contents, and GSH levels, along with a decrease in MPO activity and MDA levels in group III (P < .05).”

“ Tempol treatment upregulated levels of antioxidant proteins, including superoxide dismutase, catalase, and glutathione.”

“Moreover, tempol inhibited oxidative stress in lung tissue by down-regulating the MDA level (P<0.001) and enhancing SOD activity (P<0.001) and the GSH level (P<0.05).”