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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Temozolomide
Research Papers that Mention the Interaction
“Also, higher DNA damage and induced cell death was observed by combining BSO - a GSH inhibitor - with TMZ.”
“Similar effects were also observed using in vitro and in vivo models of melanoma, thus possibly indicating that GSH has a decisive role in TMZ resistance in a wider range of tumors.”
NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells“BCNU and BCNU + TMZ groups manifested a significant decrease (p = 0.0005) in GSH levels as compared to controls.”
“ TMZ administration caused a significant increase in total GSH levels (p = 0.0026) in BCNU + TMZ group when compared to the BCNU group.”
Cytoprotective effects of trimetazidine in carmustine cholestasis.
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