Possible Interaction: Glutathione and Sulfur

“ Sulphur amino acids are involved in the synthesis of intracellular antioxidants such as glutathione and N-acetyl cysteine.”

“Blocking the BSH group of glutathione with N-ethylmaleimide or removal of GSH by dialysis prevented the formation of sulphaemoglobin in the presence of elementary sulphur.”

“Simultaneously, there is an increase in cortex of the amounts of GSH with the reduction of ROS and SS.”

“In summary, dietary alterations of sulfur lowered the glutathione concentration in the liver as well as decreased sulfate levels in serum, liver, and urine, but had minimal effect on hepatic PAPS concentrations.”

“It was shown that addition of sulfur-containing amino acids , selenium and vitamin E to the ration of healthy and tumor-bearing rats (Walker carcinosarcoma 256) induced a decrease in the level of the SH-groups in the liver just likely promoting efficient extrahepatic usage of glutathione.”

“ Glutathione inhibits the binding of the sulfur containing cleavage fragment to acid insoluble material in vitro.”

“ GSH retards this inactivation and decreases the extent to which sulfur and vinyl carbon combine with proteins of the enzyme concentrate.”

“The determination of GSH is often interfered with by other active sulfur species.”

“Furthermore, the content of chlorophyll, superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), glutathione (GSH), and soluble protein increased with the addition of sulfur.”

“Trans-persulfidation reactions occur when sulfur atoms are transferred to nucleophilic acceptors such as glutathione , proteins or small metabolites.”