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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Sulfasalazine
Research Papers that Mention the Interaction
“ Sulfasalazine exerted cytotoxic effects against MBT‐2V cells by inhibiting glutathione levels and inducing the production of reactive oxygen species.”
Sulfasalazine could modulate the CD44v9‐xCT system and enhance cisplatin‐induced cytotoxic effects in metastatic bladder cancer“ Sulfasalazine (SAS), a cystine transporter (Xc−) inhibitor, is known to suppress cellular glutathione ( GSH ) biosynthesis.”
“We also found that the synergistic effect of SAS and VC led to significant cellular GSH depletion, resulting in increased ROS accumulation.”
“Also, we observed high protein expression of the catalytic subunit of xc- in all the examined GBM cell lines, and treatment with SAS blocked its activity and decreased intracellular GSH levels.”
“ SAS has also been associated with a decrease of intracellular glutathione ( GSH ) levels through a potent inhibition of xc- glutamate/cystine exchanger leading to an antioxidant deprotection.”
“The following were used to inhibit GSH and Trx metabolism: buthionine sulfoximine (BSO), a GSH synthesis inhibitor; sulfasalazine (SSZ), an inhibitor of xc– cysteine/glutamate antiporter; auranofin (Au), a thioredoxin reductase inhibitor; or 2-AAPA, a GSH-reductase inhibitor.”
“ Sulfasalazine was able to reduce glutathione levels in tumor tissue and slow tumor growth in vivo in a commonly used intracranial xenograft animal model for human gliomas when administered by intraperitoneal injection.”
“Moreover, SAS , but not TMZ, depleted the total glutathione level.”
“Thus, the individual inhibition of xCT by siRNA and a pharmacological inhibitor sulfasalazine ) only partially inhibited GSH synthesis and moderately enhanced the GBM cell sensitivity to TMZ.”
“ SSZ effectively depleted cellular GSH , leading to significant accumulation of reactive oxygen species and growth inhibition in CRC cells.”
“Furthermore, the glioma cell lines were dependent on xc−-mediated cystine uptake for viability, because cystine omission from the culture medium resulted in cell death and treatment with sulfasalazine depleted GSH levels and inhibited their growth.”
“ Sulfasalazine decreased glutathione concentrations and resistance to H2O2 in B16F10 melanoma cells, but not in mouse embryonic fibroblasts.”
Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
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