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“Based on these data, we propose an estrogen-receptor independent synergistic interaction between glutathione and E2 that dramatically increases the neuroprotective potency of the steroid and may provide insight for the development of new treatment strategies for neurodegenerative diseases.”
“The results of this paper suggest that fluctuations in the cytosolic levels of ascorbic acid, glutathione , or glutathione reductase could play a role in the regulation of steroid 21-hydroxylase activity in vivo .”