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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glutathione
supplement:
Sodium Selenite
Research Papers that Mention the Interaction
“It was demonstrated that incubation of blood platelets with sodium selenite (1-100 microM) resulted in a dose- and time-dependent loss of platelet thiols (both glutathione and protein -SH groups).”
Response of human blood platelet membrane to sodium selenite.“ Sodium selenite concentrations of 0.1 mM also decreased the intracellular glutathione concentration of target cells during an oxidant stress, and reducing target cell glutathione concentrations with buthionine sulfoximine increased their sensitivity to oxygen-related chromosomal damage.”
“ Glutathione strongly enhanced the induction of unscheduled DNA synthesis (UDS) in cultured human cells by inorganic selenium compounds: sodium selenate, sodium selenite and sodium selenide.”
“The antioxidants, vitamin C and sodium selenite , directly increased GSH content while diminishing ROS formation and DNA damage in H. pylori-infected SGC-7901 cells, indicating that vitamin C and sodium selenite can protect gastric cells against H. pylori damage.”
“Addition of sodium selenite to human red cells, under ATP deplete conditions, induces a rapid oxidation of both glutathione and protein sulphydryl groups.”
“ SS treatment significantly increased the glutathione level and decreased high malondialdehyde level in tissues of the SS+4-NP group as compared with 4-NP group.”
Protective Effect of Sodium Selenite on 4-Nonylphenol-Induced Hepatotoxicity and Nephrotoxicity in Rats.“In addition, sodium selenite injection caused reduced antioxidant enzymes (superoxide dismutase (SOD) and glutathione peroxidase (GPx)), glutathione ( GSH ) depletion, and malondialdehyde (MDA) production in the lens.”
“ Sodium selenite supplementation markedly reduced total bilirubin and ALT activity and restored the antioxidant enzymes (SOD and GSH ) and MDA and catalase activity.”
“ Sodium selenite significantly reversed the oxidative stress effects of radiation that was evidenced by increasing in lipid peroxide level and decreasing in glutathione level, and glutathione peroxidase (GPx) activity.”
“ Sodium selenite , L-selenocystine, L-selenomethionine, and Se-methyl-L-selenocysteine all enhanced glutathione S-transferase activity.”
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