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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Sodium Fluoride
Research Papers that Mention the Interaction
“Our results indicated that NaF caused significant increases in systolic blood pressure, diastolic blood pressure, mean arterial pressure, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products, together with significant reductions in glutathione peroxidase, superoxide dismutase, catalase, glutathione reductase, reduced glutathione , and nitric oxide (NO) bioavailability.”
Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications“In summary, NaF decreased the antioxidant activity of epididymis, especially glutathione and glutathione-related enzymes, as well as iTRAQ results, providing new explanations for the low sperm quality induced by fluoride.”
“ NaF exposure caused the generation of reactive oxygen … TGF-β; decreased activities of antioxidant systems ( glutathione , glutathione-S-transferase, superoxide dismutase, catalase), succinate dehydrogenase, membrane microviscosity, and membrane potential; increased activity of lipid … oxidase; and increased hepatic and nephrite toxicities (P<0.001) compared to those in normal animals.”
“ NaF exposure led to enhanced oxidative stress as shown by significant increase in the LPO and SOD activities while GPx and CAT activities and GSH levels were significantly decreased.”
“The levels of lipid peroxidation were increased, while the content of reduced glutathione , total, and protein thiol was decreased with NaF treatment.”
“Intoxication with NaF caused a significant increase in the levels of thiobarbituric acid reactive substances (46 % versus to control) and reduced the glutathione concentration (47 %) and the activities of superoxide dismutase (46 %) and catalase (41 %) in renal tissues homogenates.”
“The … NaF and As(2)O(3) impaired significantly (p<… production of free radical scavengers such as glutathione and ascorbic acid as well as antioxidant enzymes, namely, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) …), thereby increasing ovarian lipid peroxides (LPO) which might have rendered the ovary susceptible to injury.”
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