Possible Interaction: Glutathione and Silymarin

“ Silymarin … GSH at 6 months (4.5 +/- 3.4 to 5.8 +/- 4.0 micromol/g Hb) whereas, in the placebo group, GSH remained unchanged (4.….9 to 4.4 +/- 4.1 micromol/gHb) (p < 0.001), and platelet-derived non-induced MDA decreased by 33% (p < 0.015).”

“Moreover, we found that GSH was probably conjugated on either ring A or ring E of silymarin based on the mass spectrometric fragments.”

“Our recent study suggested that silymarin induces hepatic synthesis of glutathione by increasing cysteine availability, which may consequently contribute to increased antioxidant capacity of the liver.”

“ Silymarin 420 mg/day has also been shown to significantly increase serum levels of glutathione and glutathione peroxidase and SOD activity of erythrocytes and lymphocytes compared with placebo in patients with chronic alcoholic liver disease.”

“ Silymarin has also been shown to increase patient serum levels of glutathione and glutathione peroxidase.”

“Additional laboratory parameters (such as serum TAC and plasma GSH ) were also significantly elevated after therapy with silymarin.”

“ Silymarin application extensively reduced GSH depletion and ROS production as well as lipid peroxidation in irradiated cells.”

“In other hand, treatment with silymarin resulted in a significant elevation in CAT, SOD, GPx, GSH and a significant reduction in MDA, ALT, AST, ALP, total bilirubin, nitrite content, serum TNF-α, and gene expression of TNF-α in comparison with second group.”

“ Silymarin could hinder the glutathione and hydrogen peroxide-induced heme detoxification.”

“Thymoquinone and silymarin showed the positive increase in liver glutathione levels.”

“Our data revealed that SM could reduce ROS and MDA levels and increase GSH levels in AA-induced PC12 cells.”