Possible Interaction: Glutathione and Serine

“Replacement of Cys-47 with alanine or serine decreases the affinity for GSH and triggers a positive kinetic cooperativity with respect to this substrate.”

“The intracellular pool of glutathione was extremely reduced by depletion of cystine, or of glycine and serine , but to a far less extent by depletion of glutamate.”

“ L-serine alone led to a smaller increase in glutathione level, and borate alone was without effect.”

“ L-serine in borate buffer inhibits γ-glutamyl transpeptidase, the major catabolic enzyme for glutathione.”

“Most of these metabolites are involved in purine and pyrimidine metabolism, glutathione and taurine metabolism, as well as phospholipid and sphingolipid metabolism, which may contribute to the growth-promoting effects of serine on offspring.”

“ L-serine increased glutathione and S-adenosylmethionine by 94.0% and 30.6%, respectively, compared with the ethanol group.”

“4) Glutathione content in both oocytes and cumulus cells was significantly reduced by incubation with 5mM Ser (Exp.4). (”

“Greater Ser concentration in IVM medium altered "normal" intracellular GSH in both oocytes and cumulus cells with negative consequences for subsequent developmental capacity.”

“ GSH inhibited the serine phosphorylation of I kappa B-alpha by TNF-alpha, leading to the downregulation of NF-kappa B-DNA binding activity followed by decreased expression of p65/p50 and I kappa B mRNAs.”

“Our work reveals an unexpected role for GSH in restricting serine availability to preserve Treg functionality.”

“Application of radiolabeled serine to leaf pieces revealed severely reduced incorporation rates into Cys and even more so into glutathione.”