Possible Interaction: Glutathione and Selenomethionine

“Compared to … group, SeMet increased … GSH concentration (P = 0.002), the activities of glutathione peroxidase (P = 0.031), γ-glutamate cysteine ligase (P < 0.001), and thioredoxin reductase (… < 0.001), and decreased the concentrations of ROM, MDA, and PC in the serum and liver of geese (P < 0.05).”

“ l-Selenomethionine supplementation significantly increased GSH concentration in liver and breast muscle (p < 0.05); SOD activity in liver (p < 0.01); and T-AOC in liver, pancreas, and breast muscle (p < 0.05) of broilers, compared with broilers fed d-Se-Met diet.”

“In breast muscle, the addition of Se-Met significantly elevated T-AOC, GPX, T-SOD, CAT activities, contents of metallothionein and GSH (p < 0.05), and reduced carbonyl protein content (p < 0.05).”

“Sodium selenite, L-selenocystine, L-selenomethionine , and Se-methyl-L-selenocysteine all enhanced glutathione S-transferase activity.”

“ Selenomethionine caused the maintenance of high steady state GSH level and a normal GPx activity during the fist phase of tumour growth.”

“In contrast, selenite, but not selenomethionine , induced a modest increase in liver glutathione concentrations.”

“ Se-Met increased the cellular levels of glutathione in the control, an oxidatively stressed RPE.”

“This study demonstrates that Se-Met enhances the antioxidant capacity of RPE by inducing the transporter xc- with a consequent increase in glutathione.”

“ GSH is shown to reduce SeMetO and SeTalO, with consequent formation of GSSG with apparent second order rate constants, k2, in the range 103–104 M−1 s−1.”

“A highly significant increase in total glutathione was observed with selenomethionine supplementation, compared with sodium selenite.”