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Last Updated: 2 years ago

Possible Interaction: Glutathione and Salicylic Acid

Research Papers that Mention the Interaction

SA and 5-ASA decreased the GSH content in renal cells and increased it in HepG2.
Cell Biology and Toxicology  •  2004  |  View Paper
An increased level of GSH was observed after menadione pretreatment; this increase was blocked by salicylate , thereby linking the GSH increase to activation of NF-kappaB by menadione.
Molecular pharmacology  •  1997  |  View Paper
Salicylate is a potent depletor of glutathione.
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  1996  |  View Paper
Hydroxylation of both phenylalanine and salicylate by stimulated human PMNs were significantly accelerated by incubation in the presence of the reduced form of glutathione ( GSH).
Biological & pharmaceutical bulletin  •  1994  |  View Paper
SA (0.5 mM) enhanced the endogenous level of SA that restored the chlorophyll content and catalase activity … peroxidase and glutathione S-transferase), formation of non-enzymatic antioxidants (anthocyanins, carotenoids, flavonoids, phenolics, ascorbate and reduced glutathione ) and osmolytes (proline, amino acids and glycine … by scavenging the accumulated hydrogen peroxide.
Environmental Science and Pollution Research  •  2021  |  View Paper
In addition, SA application to Ni-stressed plants had an additive effect on the activities of the ascorbate and glutathione pools , and the AsA-GSH cycle enzymes (ascorbate peroxidase, monodehydroascorbate reductase, dehydroascorbate reductase, glutathione reductase), superoxide dismutase, catalase, glutathione S-transferase, and osmolyte biosynthesis).
Ecotoxicology and environmental safety  •  2019  |  View Paper
Furthermore, SA reversed the detrimental effects of Cd on total ascorbate, glutathione , the ascorbic acid/oxidized dehydroascorbate and glutathione/glutathione disulphide ratios, lipid peroxidation, malondialdehyde concentration, lipoxygenase activity, and the accumulation of proline.
Ecotoxicology and environmental safety  •  2018  |  View Paper
Furthermore, ASA, GSH and their redox ratios (ASC/DHA and GSH/GSSG) enhanced with SA pretreatments.
In addition, protective role of SA was also related to promotion of ascorbate– glutathione cycle.
Botanical Studies  •  2016  |  View Paper
The in vitro release of SA from decanethiol gated MSNs indicated that the release rate of SA in an environment with a certain amount of GSH was significantly higher than that without GSH.
ACS applied materials & interfaces  •  2015  |  View Paper
While no effects on NADP(H) or ascorbate were observed, and H(2)O(2)-induced decreases in growth were maintained, blocking GSH modulation antagonized salicylic acid (SA) accumulation and SA-dependent responses.
Antioxidants & redox signaling  •  2013  |  View Paper
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