Possible Interaction: Glutathione and Rutin

“A pre‐treatment with rutin (16.3 &mgr;M) significantly attenuate the altered level of glutathione , sulfhydryl, malondialdehyde and carbonyl content.”

“The results showed that rutin inhibited the release of ROS and increased the secretion of oxidative stress factors [superoxide dismutase (SOD) and glutathione (GSH)] and promoted the proliferation of PDLSCs in an inflammatory environment.”

“ Rutin reduced UV-induced proinflammatory response and ROS generation and enhanced the activity/levels of antioxidants (SOD, GSH-Px, vitamin E, GSH , and Trx).”

“ Rutin effectively prevented against decrease in glutathione peroxidase, glutathione and vitamins E and C activities/levels, particularly 2 h following UVA irradiation.”

“In addition, in the presence of rutin , H2O2-induced intracellular excessive ROS and MDA were attenuated, whereas intracellular SOD and GSH depletion were prevented.”

“Our research indicated that rutin protected the intracellular GSH antioxidant system and prevented H(2)O(2)-induced apoptosis of HUVECs through regulating reactive oxygen species mediated mitochondrial dysfunction pathway.”

“ Rutin also prevented the increased DNA fragment formation and glutathione ( GSH ) depletion and inhibited the collapse of mitochondrial membrane potentials (DeltaPsim) that occurred in HUVECs exposed to H(2)O(2), which protected HUVECs against oxidative damage and the further mitochondrial membrane integrity impairment, leading to apoptosis.”

“ Rutin , after tBHP induction, prevented the GSH decrease and the formation of HB.”

“ Rutin also inhibited the reduction of total glutathione by nitric oxide.”

“In contrast, RH significantly enhanced levels GSH and activities of SOD, GSH-Px, decreased levels of MDA and inhibited mitochondrial permeability transition pore (mtPTP) in the brains of both control and CdCl2-treated rats.”

“Administration of GbE, rutin and quercetin remarkably inhibited the AR activity, stimulated the production of glutathione , and decreased the levels of MDA and AGEs in the lenses of DC-induced rats, which eventually delayed the progression of lens opacification in diabetic rats to various degrees.”