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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Rolipram
Research Papers that Mention the Interaction
“Furthermore, rolipram significantly reduced the oxidative stress induced by Aβ25–35, as evidenced by the decrease in the levels of reactive oxygen species (ROS) and malondialdehyde (MDA), and restored the reduced GSH levels and superoxide dismutase (SOD) activity.”
Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats“Additionally, rolipram reduced oxidative-nitrosative stress markers (lipid peroxidation and nitrite levels) and restored the antioxidant enzyme level, including reduced glutathione ( GSH ), superoxide dismutase (SOD) and catalase (CAT), indicating attenuation of oxidative-nitrosative stress.”
Type 4 phosphodiesterase enzyme inhibitor, rolipram rescues behavioral deficits in olfactory bulbectomy models of depression: Involvement of hypothalamic–pituitary–adrenal axis, cAMP signaling aspects and antioxidant defense system
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