Possible Interaction: Glutathione and Rifampin

“Retrospective study of tuberculosis patients who underwent INH and RFP treatment also revealed an association between the intake of glutathione and a negative ATB-DILI rate.”

“… GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and … S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in … P-450 contents and increased production of lipid peroxidation.”

“ Rifampin significantly attenuated acetaminophen-mediated GSH depletion in a concentration-dependent manner.”

“Only the highest dose of gludopa (7.5 nmol/kg), which resulted in a 7.3-fold increase in UDAV and 1.7-fold increase in RIF DA , was associated with significant diuresis and natriuresis.”

“5 Superoxide dismutase, catalase and glutathione per oxidase activities in the hepatic tissue decreased with RMP treatment.”

“This treatment decreased RIF and MCA tumor GSH concentrations by 95% and 80%, respectively.”

“ RIF at various concentrations decreased the activities of gamma glutamyl cysteine synthetase (GGCS) and GSH synthetase.”

“Maximum depletion of NPSH levels was observed when 3 day grown cultures were … a period of 6 h. The results of this study clearly demonstrate that RIF … GSH levels regardless of the fact that the drug is included in … cells have been grown for a period of three days.”

“When the same samples were assayed for GSH levels (glyoxylase assay) the depletion of GSH levels by RIF was still observed, confirming the earlier findings.”