Possible Interaction: Glutathione and Resveratrol

“In addition, RSV promoted an excessive cellular ROS (2–3 times) production corresponding with a significant decrement in the SOD activity (but not in its content) and GSH levels; whereas the catalase, glutahione reductase, glutathione peroxidase and glutathione‐S‐transferase activities (but not their contents) remained unchanged.”

“They found that resveratrol significantly reduced the fibrosis score, nitric oxide and tumor necrosis factor-a levels, and increased the glutathione and superoxide dismutase levels in the hyperoxia group.”

“In macrophages and skin cells, resveratrol (50 μmol L-1) induced a time-dependent increase in reduced glutathione levels but did not alter the background levels of thiobarbituric acid-reactive substances.”

“The in vitro release profile confirmed that RV release was enhanced in response to external glutathione (GSH).”

“ Resveratrol directly upregulates antioxidative capacity by increasing antioxidant genes such as heme oxygenase-1, superoxide dismutase, catalase, and glutathione.”

“These alterations in HO-1 and NO markers were prevented by cotreatment with the polyphenol resveratrol , which also improved GSH levels.”

“Further studies reveal that resveratrol decreases the absorption of glutamine and glutathione content by reducing the expression of glutamine transporter ASCT2.”

“ Resveratrol and caffeic acid prevented malondialdehyde accumulation and preserved glutathione , glutathione peroxidase, and catalase activities in erythrocytes.”

“Further analysis of the roles of resveratrol demonstrated that it modulated biosynthesis, recycling, and consumption of glutathione (GSH), thereby promoting GSH homeostasis in HBE cells treated by As2O3.”

“Therapeutical interventions that aim to increase GSH concentrations in vivo include N-acetyl cysteine; Nrf-2 activation via hyperbaric oxygen therapy; dimethyl fumarate; phytochemicals, including curcumin, resveratrol , and cinnamon; and folate supplementation.”