Possible Interaction: Glutathione and Propyl Gallate

“In conclusion, PG induced growth inhibition and death of ECs, especially CPAEC via GSH depletion.”

“ PG also dose-dependently increased GSH depleted cells in both ECs.”

“Furthermore, PG increased the GSH depleted cell number and decreased GSH level in CPAEC.”

“ PG also increased GSH depleted cell numbers in HeLa cells.”

“ PG significantly increased GSH depleted cells in a time- and dose-dependent manner.”

“ PG depleted intracellular GSH content in HeLa cells at 24 h. Treatment with caspase inhibitor reduced ROS levels and significantly prevented GSH depletion in PG-treated HeLa cells at 24 h. In conclusion, PG induced apoptosis in HeLa cells.”

“ PG caused depletion in GSH content in HeLa cells.”

“In whole body homogenates, propyl gallate (PG; 25 micrograms/ml) increased the glutathione content significantly up to the 22nd day of life whereas in mitochondria it increased during all age intervals in the two sexes with the exception of the 36th and 43rd day of survival in males.”

“Moreover, a marked inhibition of G-6-Pase activity was found also when propyl gallate and reduced glutathione were added, at different concentrations, to incubation mixture.”

“ PG increased ROS levels and caused GSH depletion in both cell lines at 24 h. MAPK inhibitors increased O2•- levels and GSH depletion in PG-treated Calu-6 cells, and JNK and p38 inhibitors increased ROS levels and GSH depletion in PG-treated A549 cells.”

“In conclusion, PG inhibited the growth of CPAECs by regulating GSH levels.”